Allicin

Allicin is a natural product originally isolated from A. sativum that has wide-ranging biological effects including antioxidative, anticancer, antimicrobial, and antifungal activities. It inhibits the cysteine proteases cathepsin B and L, facipain 2, and rhodesain with Ki values of 8.6 and 9.3, 1.04, and 5.31 µM, respectively. It shows antiparasitic activity against P. falciparum (IC50 = 5.2 µM) and T. b. brucei (IC50 = 13.8 µM), the parasites that cause malaria and African sleeping sickness, respectively. Allicin (5-10 µM) dose-dependently inhibits cell adhesion, invasion, and migration in various lung adenocarcinoma cell lines. It also alters the balance of tissue inhibitors of matrix metalloproteinases (TIMPs) and matrix metalloproteinases (MMPs), decreases phosphorylation of Akt, and decreases PI3K/Akt signaling.Formal Name: 2-propene-1-sulfinothioic acid, S-2-propen-1-yl ester. CAS Number: 539-86-6. Synonyms: Diallyl Thiosulfinate. Molecular Formula: C6H10OS2. Formula Weight: 162.3. Purity: >95%. Formulation: (Request formulation change), A solution in methanol:water:formic acid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 5 mg/ml, Ethanol: 3 mg/ml. SMILES: C=CCS(SCC=C)=O. InChi Code: InChI=1S/C6H10OS2/c1-3-5-8-9(7)6-4-2/h3-4H,1-2,5-6H2. InChi Key: JDLKFOPOAOFWQN-UHFFFAOYSA-N.