all-trans Retinoic Acid-d5

all-trans Retinoic acid-d5 is intended for use as an internal standard for the quantification of all-trans retinoic acid (Cay-11017) by GC- or LC-MS. all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARalpha, RARbeta, and RARgamma, respectively, in radioligand binding assays. It induces expression of a luciferase reporter in COS-7 cells expressing RARalpha, RARbeta, or RARgamma (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid (12 nmol) reduces papilloma formation induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014) in mice. It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of alpha-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis. all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.Formal Name: (2E,4E,6E,8E)-9-(6,6-dimethyl-2-(methyl-d3)cyclohex-1-en-1-yl-3,3-d2)-3,7-dimethylnona-2,4,6,8-tetraenoic acid. Synonyms: atRA-d5, RA-d5, Vitamin A Acid-d5. Molecular Formula: C20H23D5O2. Formula Weight: 305.5. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.5 mg/ml. SMILES: CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C(O)=O)=C(C([2H])([2H])[2H])C([2H])([2H])CC1. InChi Code: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+/i3D3,10D2. InChi Key: SHGAZHPCJJPHSC-GOWYKSNKSA-N.