Aleplasinin

Description: Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic system. Aleplasinin can be used in Alzheimer's disease studies. Target: PAI-1. Smiles: Cc1cccc(c1)-c1ccc2n(Cc3ccc(cc3)C(C)(C)C)cc(C(=O)C(O)=O)c2c1. References: Jacobsen JS, et al. Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade. Proc Natl Acad Sci U S A. 2008 Jun 24,105(25):8754-9.