Alaproclate (hydrochloride)

Alaproclate is a selective serotonin reuptake inhibitor (SSRI). It inhibits depletion of serotonin (5-HT) induced by 4-methyl-alpha-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively). Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 µM, respectively) and does not inhibit GABA-evoked currents when used at concentrations up to 100 µM. It increases sirtuin 1 (SIRT1) levels in N2a murine neuroblastoma cells expressing apolipoprotein E4 (ApoE4, IC50 = 2.3 µM) and in the hippocampus in the FXFAD-ApoE4 transgenic mouse model of Alzheimer's disease when administered at a dose of 20 mg/kg twice daily. Alaproclate (40 mg/kg) decreases immobility time in the forced swim test in rats, indicating antidepressant-like activity.Formal Name: alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester, monohydrochloride. CAS Number: 60719-83-7. Synonyms: GEA 654, A03. Molecular Formula: C13H18ClNO2 . HCl. Formula Weight: 292.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: soluble. lambdamax: 222 nm. SMILES: CC(C(OC(C)(CC1=CC=C(C=C1)Cl)C)=O)N.Cl. InChi Code: InChI=1S/C13H18ClNO2.ClH/c1-9(15)12(16)17-13(2,3)8-10-4-6-11(14)7-5-10,/h4-7,9H,8,15H2,1-3H3,1H. InChi Key: OPAKSOWFKIUFNP-UHFFFAOYSA-N.