AG957

Tyrphostins are tyrosine phosphorylation inhibitors that act by inhibiting tyrosine kinases. AG957 is a tyrphostin that targets transforming Bcr-Abl fusion proteins (p185Bcr-Abl, p210Bcr-Abl), as well as normal c-Abl (IC50s = 4.3, 1, and 7.1 µM, respectively, for human proteins). It also inhibits epidermal growth factor receptor (IC50 = 0.25 µM). As the constitutively-active 210 kDa Bcr-Abl fusion protein commonly occurs in chronic myelogenous leukemia (CML) cells, AG957 is commonly used to study Bcr-Abl signaling in the CML K562 cell line. AG957 is also used to study signaling through c-Abl.Formal Name: 4-[[(2,5-dihydroxyphenyl)methyl]amino]-benzoic acid, methyl ester. CAS Number: 140674-76-6. Synonyms: NSC 654705, Tyrphostin AG957. Molecular Formula: C15H15NO4. Formula Weight: 273.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml. lambdamax: 225, 308 nm. SMILES: OC1=C(CNC2=CC=C(C(OC)=O)C=C2)C=C(O)C=C1. InChi Code: InChI=1S/C15H15NO4/c1-20-15(19)10-2-4-12(5-3-10)16-9-11-8-13(17)6-7-14(11)18/h2-8,16-18H,9H2,1H3. InChi Key: QSFREBZMBNRGOK-UHFFFAOYSA-N.