AG-1295

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas. AG-1295 is a quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGF receptor kinase in vitro and in Swiss 3T3 cells (IC50s range from 0.3-1 µM). It inhibits PDGF-stimulated DNA synthesis with an IC50 value of 2.5 µM without affecting activity of the EGF receptor.Formal Name: 6,7-dimethyl-2-phenyl-quinoxaline. CAS Number: 71897-07-9. Synonyms: NSC 380341, Tyrphostin AG-1295. Molecular Formula: C16H14N2. Formula Weight: 234.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 2 mg/ml, Ethanol: 2.5 mg/ml. lambdamax: 263, 345 nm. SMILES: CC1=CC2=NC=C(N=C2C=C1C)C3=CC=CC=C3. InChi Code: InChI=1S/C16H14N2/c1-11-8-14-15(9-12(11)2)18-16(10-17-14)13-6-4-3-5-7-13/h3-10H,1-2H3. InChi Key: FQNCLVJEQCJWSU-UHFFFAOYSA-N.