AF-DX 384

AF-DX 384 is an antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis = 6.03 and 10 nM, respectively). It is selective for M2 and M4 over M1, M3, and M5 receptors (Kis = 30.9, 66.07, and 537.03 nM, respectively). AF-DX 384 increases acetylcholine release in the hippocampus and cortex of young and aged rats in vivo when infused locally at a concentration of 1 µM and in the cortex when administered intraperitoneally at a dose of 5 mg/kg. It reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine (Cay-14108).Formal Name: N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide. CAS Number: 118290-26-9. Molecular Formula: C27H38N6O2. Formula Weight: 478.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 50 mM, Ethanol: 10 mM. SMILES: O=C1NC(C=CC=N2)=C2N(C(NCCN3C(CN(CCC)CCC)CCCC3)=O)C4=C1C=CC=C4. InChi Code: InChI=1S/C27H38N6O2/c1-3-16-31(17-4-2)20-21-10-7-8-18-32(21)19-15-29-27(35)33-24-13-6-5-11-22(24)26(34)30-23-12-9-14-28-25(23)33/h5-6,9,11-14,21H,3-4,7-8,10,15-20H2,1-2H3,(H,29,35)(H,30,34). InChi Key: MZDYABXXPZNUCT-UHFFFAOYSA-N.