Adiphenine (hydrochloride)

Adiphenine is an anticholinergic agent. It is an antagonist of nicotinic acetylcholine receptors (nAChRs, IC50s = 1.8, 3.7, and 6.3 µM for the alpha3beta4, alpha4beta2, and alpha4beta4 subunit-containing receptors, respectively), as well as muscarinic acetylcholine receptors (Ki = 0.44 µM). Adiphenine inhibits contractions induced by acetylcholine (ACh) in isolated guinea pig ileum in a concentration-dependent manner. It prevents tonic hindlimb extension in a mouse model of seizures induced by maximal electroshock (MES) with an ED50 value of 62 mg/kg but is neurotoxic at higher doses. Adiphenine protects against organophosphate-induced lethality in mice with a 50% protective dose (PD50) value of 3.3 mg/kg. It has also been used as a local anesthetic.Formal Name: alpha-phenyl-benzeneacetic acid, 2-(diethylamino)ethyl ester, monohydrochloride. CAS Number: 50-42-0. Synonyms: NSC 129224, Spasmolytin, Trasentin. Molecular Formula: C20H25NO2 . HCl. Formula Weight: 347.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O=C(OCCN(CC)CC)C(C1=CC=CC=C1)C2=CC=CC=C2.Cl. InChi Code: InChI=1S/C20H25NO2.ClH/c1-3-21(4-2)15-16-23-20(22)19(17-11-7-5-8-12-17)18-13-9-6-10-14-18,/h5-14,19H,3-4,15-16H2,1-2H3,1H. InChi Key: LKPINBXAWIMZCG-UHFFFAOYSA-N.