Adenosine-5'-O-(3-thiotriphosphate) (sodium salt)

Adenosine-5'-O-(3-thiotriphosphate) (ATPgammaS) is an agonist of the purinergic P2Y11 receptor. It induces inositol phosphate accumulation in CHO-K1 cells expressing the human or canine P2Y11 receptor (EC50s = 1.2 and 19.3 µM, respectively). ATPgammaS (10 µM) inhibits Junin virus-induced increases in mRNA encoding bone morphogenetic protein 6 (BMP6) and reduces particle forming units (PFUs) in Junin virus-infected primary rat osteoblasts. It induces insulin secretion by MIN6 pancreatic beta-cells when used at a concentration of 25 µM.Formal Name: adenosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid, tetrasodium salt. CAS Number: 88453-52-5. Synonyms: Adenosine 5'-(gamma-thio)-triphosphate, ATPgammaS. Molecular Formula: C10H12N5O12P3S . 4Na. Formula Weight: 611.2. Purity: >95%. Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble. SMILES: O[C@@H]1[C@@H](COP(OP(OP([O-])([S-])=O)([O-])=O)([O-])=O)O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]1O.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C10H16N5O12P3S.4Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31,,,,/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31),,,,/q,4*+1/p-4/t4-,6-,7-,10-,,,,/m1..../s1. InChi Key: PBVFEDMHGRBQSV-KWIZKVQNSA-J.