Acenocoumarol

Acenocoumarol is an anticoagulant and vitamin K antagonist. It inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase (VKOR) (IC50 = 1.5 and 5.8 nM for VKORC1 and VKORC1L1, respectively). Acenocoumarol also inhibits a variety of VKOR mutants in cell-based reporter assays (IC50s = 0.54-11.21 nM). It prolongs prothrombin time in rat blood when administered at a dose of 1.5 mg/kg.Formal Name: 4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one. CAS Number: 152-72-7. Synonyms: (±)-Acenocoumarin, (±)-Nicoumalone, G-23350. Molecular Formula: C19H15NO6. Formula Weight: 353.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 283 nm. SMILES: CC(=O)CC(c1ccc(cc1)[N+](=O)[O-])c1c(=O)oc2ccccc2c1O. InChi Code: InChI=1S/C19H15NO6/c1-11(21)10-15(12-6-8-13(9-7-12)20(24)25)17-18(22)14-4-2-3-5-16(14)26-19(17)23/h2-9,15,22H,10H2,1H3. InChi Key: VABCILAOYCMVPS-UHFFFAOYSA-N.