Ac-PAL-AMC

Description: Ac-PAL-AMC is a fluorogenic substrate for the beta1i/LMP2 subunit of the 20S immunoproteasome. Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released, and its fluorescence can quantify the activity of the beta1i/LMP2 subunit. Ac-PAL-AMC is selective for the immunoproteasome over the constitutive proteasome. AMC displays excitation/emission maxima of 351/430 nm. Target: Others. Smiles: CC=1C=2C(=CC(NC([C@@H](NC([C@@H](NC(=O)[C@H]3N(C(C)=O)CCC3)C)=O)CC(C)C)=O)=CC2)OC(=O)C1