A-867744

Description: A-867744 is an effective and selective type II positive allosteric modulator of the alpha7 nAChR (EC50: 1.0 µM). Target: Autophagy, AChR. Smiles: CCC(=O)c1cc(-c2ccc(Cl)cc2)n(c1C)-c1ccc(cc1)S(N)(=O)=O. References: Malysz J, et al. In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile. J Pharmacol Exp Ther. 2009 Jul,330(1):257-67.