A-443654

Description: A-443654, a pan-Akt inhibitor, exhibits equal potency against Akt1, Akt2, and Akt3 within cells (Ki=160 pM). Target: MAPK, Casein Kinase, PKC, Src, Akt, FLT, Chk, GSK-3, CDK, ERK, VEGFR, PKA, S6 Kinase. Smiles: C([C@@H](COC=1C=C(C=NC1)C=2C=C3C(=CC2)NN=C3C)N)C=4C=5C(NC4)=CC=CC5. References: Luo Y, et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther. 2005 Jun,4(6):977-86.