A-443654

White to off-white solid. Soluble in DMSO (15mg/ml), ethanol (10mg/ml) or DMF (20mg/ml). Potent and selective Akt inhibitor (Ki=160pmol/L for all three isoforms PKBalpha, PKBbeta and PKBgamma), DYRK1A inhibitor (IC50=10nM). Inhibits other kinases, including PRK2, MSK1 and DYRK3 at low nM range as well, Interferes with mitotic progression by regulating aurora a kinase expression and bipolar spindle formation. It induces G2/M accumulation, defects in centrosome separation and formation of either monopolar arrays or disorganized spindles, Anticancer agent. Apoptosis inducer and chemosensitizing agent. Slows the progression and growth of Akt-dependent tumors, Induces rapid Akt Ser473 phosphorylation independent of mTORC1 inhibition in human cancer cell lines, Activates mTORC2 and reverses long-term memory deficits.