8RK64

8RK64 is a covalent inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1, IC50 = 0.32 µM) and a click chemistry reagent. It is selective for UCH-L1 over UCH-L3 and UCH-L5 (IC50s = 216 and >1,000 µM, respectively). 8RK64 has been linked to fluorophores containing alkyne groups via copper(I)-catalyzed azide/alkyne cycloaddition (CuAAC) and used to visualize UCH-L1 activity in cells.Formal Name: N-[5-(2-azidoacetyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl]-1-cyano-3S-pyrrolidinecarboxamide. CAS Number: 2705841-52-5. Molecular Formula: C14H16N8O2S. Formula Weight: 360.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml, DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: [N-]=[N+]=NCC(N1CC2=C(CC1)N=C(S2)NC([C@@H]3CN(CC3)C#N)=O)=O. InChi Code: InChI=1S/C14H16N8O2S/c15-8-21-3-1-9(6-21)13(24)19-14-18-10-2-4-22(7-11(10)25-14)12(23)5-17-20-16/h9H,1-7H2,(H,18,19,24)/t9-/m0/s1. InChi Key: KIWKRCCIHSGWQS-VIFPVBQESA-N.