852A

852A is a toll-like receptor 7 (TLR7) agonist. It selectively induces NF-kappaB signaling in HEK293 cells expressing recombinant human TLR7 but not HEK293 cells expressing recombinant human TLR8 or TLR9 when used at a concentration of 1 µM. 852A (10-1,000 ng/ml) also induces IFN-alpha production in plasmacytoid dendritic cell-enriched but not plasmacytoid dendritic cell-depleted isolated human peripheral blood mononuclear cells (PBMCs). In vivo, 852A (150 mg/kg) delays the onset of lung metastasis in a B16/F10 murine melanoma model.Formal Name: N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]-methanesulfonamide. CAS Number: 532959-63-0. Synonyms: PF-4878691. Molecular Formula: C17H23N5O2S. Formula Weight: 361.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): Slightly soluble. SMILES: NC(C1=C2N(CCCCNS(C)(=O)=O)C(CC)=N1)=NC3=C2C=CC=C3. InChi Code: InChI=1S/C17H23N5O2S/c1-3-14-21-15-16(12-8-4-5-9-13(12)20-17(15)18)22(14)11-7-6-10-19-25(2,23)24/h4-5,8-9,19H,3,6-7,10-11H2,1-2H3,(H2,18,20). InChi Key: YZOQZEXYFLXNKA-UHFFFAOYSA-N.