8-Prenylnaringenin

8-Prenylnaringenin (8-PN) is a prenylflavonoid with potent estrogenic activity that can be isolated from hops. It inhibits both isoforms of the human estrogen receptor (ER, IC50s = 57 and 68 nM for ERalpha and ERbeta, respectively). 8-PN is effective in vivo, suppressing loss of bone mineral density in ovariectomized rats and blocking changes in tail skin temperature in a rat model of postmenopausal hot flashes.Formal Name: 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one. CAS Number: 68682-02-0. Synonyms: 8-PN. Molecular Formula: C20H20O5. Formula Weight: 340.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 5 mg/ml, Ethanol: 2 mg/ml. lambdamax: 294 nm. SMILES: O=C1CC(C2=CC=C(O)C=C2)OC3=C(C/C=C(C)/C)C(O)=CC(O)=C31. InChi Code: InChI=1S/C20H20O5/c1-11(2)3-8-14-15(22)9-16(23)19-17(24)10-18(25-20(14)19)12-4-6-13(21)7-5-12/h3-7,9,18,21-23H,8,10H2,1-2H3. InChi Key: LPEPZZAVFJPLNZ-UHFFFAOYSA-N. Origin: Synthetic.