8-Methoxymethyl-3-isobutyl-1-methylxanthine

8-Methoxymethyl-3-isobutyl-1-methylxanthine is an inhibitor of phosphodiesterase 1 (PDE1, IC50 = 5 µM) and a derivative of IBMX (Cay-13347). It is selective for PDE1 over PDE2, PDE3, and PDE4 but also inhibits PDE5 (IC50s = 37, >400, >400, and 2 µM, respectively). 8-Methoxymethyl-3-isobutyl-1-methylxanthine (30 µM) enhances forskolin-induced increases in intracellular calcium levels in isolated rat olfactory receptor neurons. It induces relaxation of isolated human saphenous vein segments in the absence of endothelium (EC50 = 31 µM). In vivo, 8-methoxymethyl-3-isobutyl-1-methylxanthine (200 µg/kg) enhances decreases in pulmonary artery pressure and vascular resistance induced by iloprost (Cay-18215) in a rabbit model of pulmonary hypertension induced by the TP receptor agonist U-46619 (Cay-16450).Formal Name: 3,9-dihydro-8-(methoxymethyl)-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione. CAS Number: 78033-08-6. Synonyms: 8-methoxymethyl IBMX, 8-MeOMeMIX, 8-MM-IBMX, MMPX. Molecular Formula: C12H18N4O3. Formula Weight: 266.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly soluble, Methanol: Slightly soluble. SMILES: O=C1C2=C(N(CC(C)C)C(N1C)=O)N=C(COC)N2. InChi Code: InChI=1S/C12H18N4O3/c1-7(2)5-16-10-9(11(17)15(3)12(16)18)13-8(14-10)6-19-4/h7H,5-6H2,1-4H3,(H,13,14). InChi Key: NBLBCGUCPBXKOV-UHFFFAOYSA-N.