8-Bromo-cGMP sodium

Description: 8-Bromo-cGMP sodium is a PKG activator, a membrane-permeable analog of cGMP. 8-Bromo-cGMP sodium has pain-relieving and vasodilatory effects, significantly inhibits Ca2+ macroscopic currents, and inhibits high K+-stimulated insulin release. Target: Calcium Channel, PKA. Smiles: [Na+].Nc1nc(=O)c2nc(Br)n(C3OC4COP([O-])(=O)OC4C3O)c2[nH]1. References: Choi J, et al. Effects of 8-bromo-cyclic GMP on membrane potential of single swine tracheal smooth muscle cells. J Pharmacol Exp Ther. 1998,285(2):588-594.