8-Azaadenosine

8-Azaadenosine is a purine nucleoside analog and an inhibitor of adenosine deaminase acting on RNA 1 (ADAR1), an enzyme that converts adenosine to inosine in dsRNA, a post-transcriptional modification known as A-to-I editing. It inhibits RNA A-to-I editing in, as well as the invasion and migration of, TPC-1 and Cal-62 thyroid cancer cells when used at concentrations of 1 and 2 µM. 8-Azaadenosine (2 mg/kg) increases the ex vivo secretion of IFN-gamma and TNF-alpha from CD8+ T cells isolated from mouse spleen in a model of hepatitis B virus (HBV) infection. It decreases serum levels of HBV surface antigen (HBsAg) in the same model.Formal Name: 3-beta-D-ribofuranosyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine. CAS Number: 10299-44-2. Synonyms: NSC 72961. Molecular Formula: C9H12N6O4. Formula Weight: 268.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 5 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml. lambdamax: 280 nm. SMILES: O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=NC=NC(N)=C3N=N2. InChi Code: InChI=1S/C9H12N6O4/c10-7-4-8(12-2-11-7)15(14-13-4)9-6(18)5(17)3(1-16)19-9/h2-3,5-6,9,16-18H,1H2,(H2,10,11,12)/t3-,5-,6-,9-/m1/s1. InChi Key: OAUKGFJQZRGECT-UUOKFMHZSA-N.