7-dehydro Cholesterol-d7

7-dehydro Cholesterol-d7 is intended for use as an internal standard for the quantification of 7-dehydro cholesterol (Cay-14612) by GC- or LC-MS. 7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3beta-hydroxysterol-Delta7-reductase (DHCR7) in the last step of cholesterol biosynthesis. It accumulates in Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in the DHCR7 gene and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features. 7-DHC is highly susceptible to free radical oxidation, giving rise to several oxysterols that may be involved in the pathogenesis of SLOS. 7-DHC levels are increased in brain, liver, and serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944 (Cay-14611). 7-DHC is also a provitamin that is converted to vitamin D3 (Cay-11792) by ultraviolet-B (UVB) light in a human skin equivalent system and in isolated human skin samples.Formal Name: cholesta-5,7-dien-25,26,26,26,27,27,27-d7-3beta-ol. CAS Number: 388622-58-0. Synonyms: Delta7-Cholesterol-d7, 7-DHC-d7, Provitamin D3-d7. Molecular Formula: C27H37D7O. Formula Weight: 391.7. Purity: >99% deuterated forms (d1-d7). Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly soluble, Methanol: Slightly soluble (*warmed). SMILES: O[C@H](C1)CC[C@@]2(C)C1=CC=C3[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](CCCC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])C. InChi Code: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1/i1D3,2D3,18D. InChi Key: UCTLRSWJYQTBFZ-UDEPUTHCSA-N.