6beta-hydroxy Eplerenone

Description: 6beta-hydroxy Eplerenone is a major metabolite of the mineralocorticoid receptor antagonist eplerenone .1 It is formed from eplerenone by the cytochrome P450 (CYP) isoform CYP3A4. Target: Others. Smiles: [H][C@@]12C[C@@]3(C)[C@@]([H])(CC[C@@]33CCC(=O)O3)[C@]3([H])[C@@H]([C@@H](O)C4=CC(=O)CC[C@]4(C)[C@@]13O2)C(=O)OC , t:22, . References: Cook, C.S., Berry, L.M., Kim, D.H., et al. Involvement of CYP3A in the metabolism of eplerenone in humans and dogs: Differential metabolism by CYP3A4 and CYP3A5. Drug Metab. Dispos. 30(12), 1344-1351 (2002).