6-Paradol

6-Paradol is a phenolic ketone that has been found in ginger (Z. officinale) and has diverse biological activities, including antioxidant, anti-inflammatory, and anti-hyperglycemic properties. It inhibits hydrogen peroxide-induced oxidation of cell-free calf thymus DNA when used at a concentration of 100 µM. In vitro, 6-paradol (10 µg/ml) inhibits LPS-induced nitric oxide (NO), IL-6, and TNF-alpha production by mouse BV-2 microglia. In vivo, 6-paradol (6.75 mg/kg per day) lowers blood glucose levels in an oral glucose tolerance test (OGTT) and inhibits weight-gain in a mouse model of high-fat diet-induced obesity.Formal Name: 1-(4-hydroxy-3-methoxyphenyl)-3-decanone. CAS Number: 27113-22-0. Molecular Formula: C17H26O3. Formula Weight: 278.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml. SMILES: O=C(CCCCCCC)CCC1=CC(OC)=C(O)C=C1. InChi Code: InChI=1S/C17H26O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h10,12-13,19H,3-9,11H2,1-2H3. InChi Key: CZNLTCTYLMYLHL-UHFFFAOYSA-N. Origin: Synthetic.