6-OHDA (hydrobromide)

6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson's disease in rodents. It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 µg, respectively. Intracisternal administration of 6-OHDA (200 µg) decreases dopamine (Cay-21992) and norepinephrine (Cay-16673) levels in rat brain. It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 µM. 6-OHDA (75 µM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.Formal Name: 5-(2-aminoethyl)-1,2,4-benzenetriol, monohydrobromide. CAS Number: 636-00-0. Synonyms: 6-hydroxy Dopamine, Oxidopamine, 2,4,5-Trihydroxyphenethylamine. Molecular Formula: C8H11NO3 . HBr. Formula Weight: 250.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 15 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 296 nm. SMILES: OC1=CC(O)=C(CCN)C=C1O.Br. InChi Code: InChI=1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10,/h3-4,10-12H,1-2,9H2,1H. InChi Key: MLACDGUOKDOLGC-UHFFFAOYSA-N.