6-hydroxy Buspirone

6-hydroxy Buspirone is an active metabolite of the anxiolytic buspirone. It is formed from buspirone by the cytochrome P450 (CYP) isoform CYP3A4. 6-hydroxy Buspirone binds to the serotonin (5-HT) receptor subtype 5-HT1A in rat hippocampus and dorsal raphe (EC50s = 4 and 1 µM, respectively) and is a dopamine D2, D3, and D4 receptor antagonist (IC50s = 3.1, 4.9, and 0.85 µM, respectively). It also inhibits organic cation transporter 1 (OCT1), OCT2, and OCT3 in S2 proximal tubule cells expressing the human transporters in a concentration-dependent manner.Formal Name: 6-hydroxy-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione. CAS Number: 125481-61-0. Synonyms: BMS-52821, BMY 28674. Molecular Formula: C21H31N5O3. Formula Weight: 401.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: OC(C(N1CCCCN2CCN(CC2)C3=NC=CC=N3)=O)C4(CC1=O)CCCC4. InChi Code: InChI=1S/C21H31N5O3/c27-17-16-21(6-1-2-7-21)18(28)19(29)26(17)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9,18,28H,1-4,6-7,10-16H2. InChi Key: KOZNAHJIJGCFJJ-UHFFFAOYSA-N.