6-Aminocaproic Acid

6-Aminocaproic acid is an inhibitor of the plasmin activating enzymes streptokinase, fibrinokinase, and urokinase (IC50s = ~8 µM for all in an enzyme assay). It is selective for plasmin activating enzymes over trypsin (IC50 = >500 µM). 6-Aminocaproic acid inhibits in vitro plasmin activation and fibrinolysis in a dose-dependent manner. Ex vivo, 6-aminocaproic acid reduces fibrinolysis in dog plasma following i.p. administration at doses ranging from 20-100 mg/kg. Formulations containing 6-aminocaproic acid have been used to decrease postoperative blood transfusion rates following knee surgery.Formal Name: 6-amino-hexanoic acid. CAS Number: 60-32-2. Synonyms: epsilon-Aminocaproic Acid, EACA, NSC 26154, NSC 212532, NSC 400230. Molecular Formula: C6H13NO2. Formula Weight: 131.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 202 nm. SMILES: OC(CCCCCN)=O. InChi Code: InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9). InChi Key: SLXKOJJOQWFEFD-UHFFFAOYSA-N.