6-Amino-8-trifluoromethylphenanthridine

6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine (Cay-26420). It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 µM. 6A-8tFP directly competes with protein substrates for the ribosomal active site.Formal Name: 8-(trifluoromethyl)-6-phenanthridinamine. CAS Number: 651055-83-3. Synonyms: 6A-8tFP. Molecular Formula: C14H9F3N2. Formula Weight: 262.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble. SMILES: NC1=C(C=C(C(F)(F)F)C=C2)C2=C(C=CC=C3)C3=N1. InChi Code: InChI=1S/C14H9F3N2/c15-14(16,17)8-5-6-9-10-3-1-2-4-12(10)19-13(18)11(9)7-8/h1-7H,(H2,18,19). InChi Key: VBQYJKNVRUTAHL-UHFFFAOYSA-N.