5-Octyl-alpha-ketoglutarate

Description: In addition to its role in the Krebs cycle, alpha-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes. 5-Octyl-alpha-ketoglutarate, also known as alpha-ketoglutarate octyl ester, is a stable, cell-permeable molecule that generates free alpha-ketoglutarate upon hydrolysis of the ester bond by cytoplasmic esterases. It is used in experiments to increase levels of intracellular alpha-ketoglutarate. 5-Octyl-alpha-ketoglutarate has been shown to modulate a variety of enzymes and signaling pathways, particularly in the context of glycolysis, hypoxia, and cancer. Target: Others. Smiles: C(C(OCCCCCCCC)=O)CC(C(O)=O)=O