5-Methyltetrahydrofolic Acid (hydrate)

5-Methyltetrahydrofolic acid is a biologically active form of folic acid that functions, in conjunction with vitamin B12, as a methyl-group donor involved in the conversion of homocysteine to methionine. The availability of methyl groups is essential for a variety of methylation reactions including the synthesis of DNA and proper neural tube closure. It has been used to restore nitric oxide-generating activity in cases of familial hypercholesterolemia or hyperhomocysteinemia, reducing homocysteine levels and improving vascular endothelial function.Formal Name: N-[4-[[(2-amino-3,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, hydrate. Synonyms: 5-methyl THF, Prefolic A. Molecular Formula: C20H25N7O6 . XH2O. Formula Weight: 459.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 217, 294 nm. SMILES: O=C1C2=C(NCC(CNC3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C3)N2C)NC(N)=N1.O. InChi Code: InChI=1S/C20H25N7O6.H2O/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29,/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31),1H2/t12?,13-,/m0./s1. InChi Key: CDHSQOBJKBQKTJ-ZEDZUCNESA-N.