5,6-dihydro-5-Fluorouracil

5,6-dihydro-5-Fluorouracil is an active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (Cay-14416). It is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50 = 13.5 µM). Intravenous administration of 5,6-dihydro-5-fluorouracil (90 mg/kg per week), in combination with 5-fluorouracil and the DPD inhibitor eniluracil (Cay-34251), reduces tumor growth in a rat model of colon carcinoma.Formal Name: 5-fluorodihydro-2,4(1H,3H)-pyrimidinedione. CAS Number: 696-06-0. Synonyms: 5-DHFU, 5-Fluorodihydropyrimidine-2,4-dione, 5-Fluorodihydrouracil, 5-Fluoro-5,6-dihydrouracil, 5-FUH2. Molecular Formula: C4H5FN2O2. Formula Weight: 132.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 60 mg/ml, DMSO: 53 mg/ml, Ethanol: 0.8 mg/ml, PBS (pH 7.2): 8 mg/ml. lambdamax: 203 nm. SMILES: O=C1NC(NCC1F)=O. InChi Code: InChI=1S/C4H5FN2O2/c5-2-1-6-4(9)7-3(2)8/h2H,1H2,(H2,6,7,8,9). InChi Key: RAIRJKWTBBDDAR-UHFFFAOYSA-N.