5,6-Benzoflavone

Description: 5,6-Benzoflavone (beta-Naphthoflavone) is an exogenous ligand for the aryl hydrocarbon receptor, which disrupts zinc homeostasis in human hepatocellular carcinoma HepG2 cells. 5,6-Benzoflavone (beta-Naphthoflavone) possesses anti-inflammatory and antioxidant activities, inhibits LPS-induced inflammation through the AKT/Nrf-2/HO-1-NF-kappaB signaling axis, inhibits TNF-alpha-induced ICAM-1 and VCAM-1 expression, which can be used to study neurodegenerative diseases. Target: Antioxidant. Smiles: O=c1cc(oc2ccc3ccccc3c12)-c1ccccc1. References: Ishida T,et al. beta-Naphthoflavone, an exogenous ligand of aryl hydrocarbon receptor, disrupts zinc homeostasis in human hepatoma HepG2 cells. J Toxicol Sci. 2019,44(10):711-720.