5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione

Yellow powder. Soluble in DMSO. Potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1alpha (68% inhibition of DYRK1alpha and Pim-2 at 5 µ,M), while exhibiting little or no activity against a panel of 57 other kinases (?18% inhibition at 5 µ,M). Reported to exhibit antitumor activity in PC3 human prostate cancer cultures in vitro (IC50 = 48 µ,M) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20, 50 mg/kg via daily i.p.).