4-O-Methyl honokiol

Description: 4-O-Methyl honokiol (4-O-Methylhonokiol) is a lignan-like compound obtained from Magnolia officinalis and Magnolia officinalis. It is a PPARgamma agonist with antiangiogenic, anticancer, anti-inflammatory, and neuroprotective properties, and it can inhibit the activity of NF-kappaB, which can be used in cancer research. Target: NF-kappaB, PPAR. Smiles: COc1ccc(cc1CC=C)-c1cc(CC=C)ccc1O. References: Lee NJ, et al. 4-O-methylhonokiol, a PPARgamma agonist, inhibits prostate tumour growth: p21-mediated suppression of NF-kappaB activity. Br J Pharmacol. 2013 Mar,168(5):1133-45.