4-MMPB

Description: 15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 µM. 4-MMPB (15-Lipoxygenase Inhibitor 1) has IC50s of 19.5 µM and 19.1 µM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer. Target: Apoptosis, Lipoxygenase, Others. Smiles: CN1CCN(CC1)c1nc(C)c2Nc3ccccc3Sc2n1. References: Nikpour M , Mousavian M , Mahdieh Davoodnejad... Synthesis of new series of pyrimido[4,5- b ][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism[J]. Medicinal Chemistry Research, 2013, 22(10):5036-5043.