4-IPP

4-IPP is an inhibitor of macrophage migration inhibitory factor (MIF). It acts as a suicide substrate for MIF, leading to covalent modification of the N-terminal proline required for activation of its catalytic activity. 4-IPP (10 and 100 µM) inhibits the migration and anchorage-independent growth of A549 non-small cell lung cancer (NSCLC) cells. It inhibits proliferation of, and induces apoptosis in, TPC-1 thyroid carcinoma cells when used at concentrations of 50 and 100 µM. 4-IPP (~50 mg/kg) also inhibits the tautomerase activity of MIF in mouse liver in vivo.Formal Name: 4-iodo-6-phenyl-pyrimidine. CAS Number: 41270-96-6. Molecular Formula: C10H7IN2. Formula Weight: 282.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 284 nm. SMILES: IC1=CC(C2=CC=CC=C2)=NC=N1. InChi Code: InChI=1S/C10H7IN2/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H. InChi Key: ZTCJXHNJVLUUMR-UHFFFAOYSA-N.