4-Hydroxyisoleucine

4-Hydroxyisoleucine is an amino acid that has been found in fenugreek (T. foenum graecum) seeds and has antidiabetic activity. It increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas when used at a concentration of 200 µM. In vivo, 4-hydroxyisoleucine increases PI3K activity in muscle and liver in rats when administered at a dose of 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide (Cay-11127) and streptozotocin (STZ, Cay-13104) when administered at 25 mg/kg. 4-Hydroxyisoleucine (50 mg/kg per day for four weeks) decreases plasma glucose, triglyceride, LDL, HDL, and cholesterol levels in an STZ-induced rat model of type 1 diabetes.Formal Name: 2-amino-2,3,5-trideoxy-3-methyl-L-ribonic acid. CAS Number: 55399-93-4. Synonyms: (4S)-4-Hydroxy-L-isoleucine, 4-OH-Ile. Molecular Formula: C6H13NO3. Formula Weight: 147.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 5mg/mL. SMILES: C[C@H](O)[C@H](C)[C@H](N)C(O)=O. InChi Code: InChI=1S/C6H13NO3/c1-3(4(2)8)5(7)6(9)10/h3-5,8H,7H2,1-2H3,(H,9,10)/t3-,4-,5?/m0/s1. InChi Key: OSCCDBFHNMXNME-QRHDOFTISA-N. Origin: Synthetic.