4-Hydroxybenzyl Alcohol

4-Hydroxybenzyl alcohol is a phenol and an aglycone form of gastrodin (Cay-28828) that has been found in Gastrodia and has diverse biological activities. It inhibits LPS-induced production of nitric oxide (NO) and reactive oxygen species (ROS) and decreases inducible nitric oxide synthase (iNOS), but not COX-2, levels in RAW 264.7 cells when used at concentrations of 0.5 and 1 mM. 4-Hydroxybenzyl alcohol (1.5 and 4.5 mg/animal) reduces exudate volume and leukocyte infiltration in a rat model of carrageenan-induced air pouch inflammation, and inhibits acetic acid-induced writhing in mice when administered at doses of 50 and 100 mg/kg. It reduces infarct volume and the number of TUNEL-positive neurons in the ipsilateral cortex in a rat model of focal cerebral ischemia induced by transient middle cerebral artery occlusion (MCAO) when administered at a dose of 50 mg/kg. 4-Hydroxybenzyl alcohol (50 and 100 mg/kg) increases the number of entries into, and the percentage of time spent in, the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.Formal Name: 4-hydroxy-benzenemethanol. CAS Number: 623-05-2. Synonyms: NSC 227926, p-Hydroxybenzyl Alcohol. Molecular Formula: C7H8O2. Formula Weight: 124.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.09 mg/ml, Ethanol: 15 mg/ml. lambdamax: 226 nm. SMILES: OC1=CC=C(CO)C=C1. InChi Code: InChI=1S/C7H8O2/c8-5-6-1-3-7(9)4-2-6/h1-4,8-9H,5H2. InChi Key: BVJSUAQZOZWCKN-UHFFFAOYSA-N. Origin: Synthetic.