4-deoxy Pyridoxine (hydrochloride)

4-deoxy Pyridoxine (DOP) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine (Cay-20706), pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells. DOP (5 mg, i.p.) reduces lysyl oxidase activity by 26% and reduces collagen and elastin crosslinking, resulting in limb abnormalities in chick embryos. It decreases latency to first seizure in mice (ED50 = 1 mmol/kg) and increases the occurrence and duration of myoclonic responses in baboons with photosensitive epilepsy. DOP reduces TNF-alpha and IL-6 production in mice infected with T. spiralis.Formal Name: 5-hydroxy-4,6-dimethyl-3-pyridinemethanol, monohydrochloride. CAS Number: 148-51-6. Synonyms: 4-Deoxypyridoxine, DOP, 4-DPD. Molecular Formula: C8H11NO2 . HCl. Formula Weight: 189.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 286 nm. SMILES: OCC1=C(C)C(O)=C(C)N=C1.Cl. InChi Code: InChI=1S/C8H11NO2.ClH/c1-5-7(4-10)3-9-6(2)8(5)11,/h3,10-11H,4H2,1-2H3,1H. InChi Key: QZKKOQQIVLXUEI-UHFFFAOYSA-N.