4µ8C

4µ8C is an inhibitor of inositol requiring enzyme 1 alpha (IRE1alpha), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress. 4µ8C inhibits IRE1alpha splicing of Xbp1 mRNA (IC50 = 6.8 µM) and reduces subsequent gene expression of Erdj4 (IC50 = 3.4 µM) in stress-cultured MEF cells but does not block IRE1alpha autophosphorylation. It reduces IL-4 production in CD4+ T cells isolated from murine spleen and LPS-stimulated increases in TNF-alpha and IL-6 mRNA expression and protein secretion in isolated alveolar macrophages from patients with cystic fibrosis.Formal Name: 7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde. CAS Number: 14003-96-4. Synonyms: IRE1 Inhibitor III. Molecular Formula: C11H8O4. Formula Weight: 204.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:8): 0.1 mg/ml, DMSO: 25 mg/ml, Ethanol: 10 mg/ml. lambdamax: 274 nm. SMILES: OC1=CC=C(C(C)=CC(O2)=O)C2=C1C=O. InChi Code: InChI=1S/C11H8O4/c1-6-4-10(14)15-11-7(6)2-3-9(13)8(11)5-12/h2-5,13H,1H3. InChi Key: RTHHSXOVIJWFQP-UHFFFAOYSA-N.