4,5,6,7-Tetrabromobenzimidazole

Casein kinase 2 (CK2) is a constitutive protein kinase involved in many signal transduction pathways. CK2 is known to negatively regulate apoptosis, and its activity is increased in many proliferating tissues and tumors. 4,5,6,7-Tetrabromobenzimidazole is a selective, ATP-competitive inhibitor of CK2 with Ki values ranging from 0.5-1 µM in rat liver, S. cerevisiae, C. tropicalis, and N. crassa. It is inactive against PKA and PKC and a relatively weak inhibitor of CK1 (Ki = 54.4-64.2 µM).Formal Name: 4,5,6,7-tetrabromo-1H-benzimidazole. CAS Number: 577779-57-8. Synonyms: Casein Kinase II Inhibitor XII, TBBz. Molecular Formula: C7H2Br4N2. Formula Weight: 433.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble, Ethanol: Soluble. SMILES: BrC1=C2C(N=CN2)=C(Br)C(Br)=C1Br. InChi Code: InChI=1S/C7H2Br4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13). InChi Key: LOEIRDBRYBHAJB-UHFFFAOYSA-N.