3PO

Description: 3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 µM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50: 1.4-24 µM). It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH. Target: Autophagy, Glucokinase. Smiles: O=C(\C=C\c1cccnc1)c1ccncc1. References: Clem B, et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol Cancer Ther. 2008 Jan,7(1):110-20.