3CAI

3CAI is an inhibitor of Akt1 and Akt2 with anticancer activity. It inhibits Akt1 and Akt2 in a kinase assay in a concentration-dependent manner, but has no effect on MEK1, JNK1, ERK1, or PDZ binding kinase (PBK) when used at a concentration of 1 µM. 3CAI (4 µM) increases apoptosis in HCT116 and HT-29 colon cancer cells and inhibits the growth of HCT116 cells in vitro in a concentration-dependent manner. Oral administration of 3CAI (30 mg/kg) reduces tumor growth in an HCT116 mouse xenograft model. It also decreases status epilepticus-induced vasogenic edema to 0.46-fold of vehicle control levels and reduces increases in endothelial nitric oxide synthase (eNOS) levels in the piriform cortex in rats when administered at a dose of 25 µM.Formal Name: 2-chloro-1-(1H-indol-3-yl)-ethanone. CAS Number: 28755-03-5. Synonyms: 3-chloroacetyl Indole. Molecular Formula: C10H8ClNO. Formula Weight: 193.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMF:PBS (pH 7.2), (1:7): 0.125 mg/ml, DMSO: 33 mg/ml, Ethanol: 17 mg/ml. lambdamax: 244, 304 nm. SMILES: O=C(CCl)C1=CNC2=CC=CC=C21. InChi Code: InChI=1S/C10H8ClNO/c11-5-10(13)8-6-12-9-4-2-1-3-7(8)9/h1-4,6,12H,5H2. InChi Key: LLZQFAXTCYDVTR-UHFFFAOYSA-N.