3-chloro-5-hydroxy BA

GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 ~ 1.5 mM) but not by other hydroxycarboxylic acids. 3-chloro-5-hydroxy BA is an agonist of GPR81 (EC50 = 16 µM) that is inactive against the related GPR109a (HCAR2) receptor. It is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks. 3-chloro-5-hydroxy BA, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells.Formal Name: 3-chloro-5-hydroxy-benzoic acid. CAS Number: 53984-36-4. Synonyms: 3-chloro-5-hydroxy Benzoic Acid, CHBA, GPR81 Agonist. Molecular Formula: C7H5ClO3. Formula Weight: 172.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 30 mg/ml. lambdamax: 210, 305 nm. SMILES: ClC1=CC(O)=CC(C(O)=O)=C1. InChi Code: InChI=1S/C7H5ClO3/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,9H,(H,10,11). InChi Key: RJOLIYHZZKAIET-UHFFFAOYSA-N.