3,5-Dinitrocatechol

3,5-Dinitrocatechol is a potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 12 nM). It is selective for COMT over tyrosine hydroxylase, dopamine beta-hydroxylase, dopamine decarboxylase, monoamine oxidase A (MAO-A), and MAO-B (IC50s = >14 µM for all). 3,5-Dintrocatechol (30 mg/kg), in combination with L-DOPA (Cay-13248) and carbidopa (Cay-23783), reduces 3-O-methyldopa (3-OMD) levels in rat serum, compared with control animals receiving only L-DOPA and carbidopa. Chronic administration of 3,5-dinitrocatechol (15 mg/kg per day for seven days) induces COMT-dependent thermal hyperalgesia and increases preference for dark in a light/dark preference test, indicating anxiety-like behavior, in rats, effects that can be prevented by the beta-adrenergic receptor antagonist propranolol (Cay-23349).Formal Name: 3,5-dinitro-1,2-benzenediol. CAS Number: 7659-29-2. Synonyms: OR-486. Molecular Formula: C6H4N2O6. Formula Weight: 200.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 1 mg/ml. lambdamax: 214, 272, 339 nm. SMILES: OC1=C(O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O. InChi Code: InChI=1S/C6H4N2O6/c9-5-2-3(7(11)12)1-4(6(5)10)8(13)14/h1-2,9-10H. InChi Key: VDCDWNDTNSWDFJ-UHFFFAOYSA-N.