3-(2-Naphthalenyl)-1-(3-pyridinyl)-2-propen-1-one

Description: DMU2105 is a specific CYP1B1 inhibitor(CYP1B1 and CYP1A1 with IC50 of 10 nM and 742 nM, respectively). Target: P450. Smiles: C(=CC(=O)C=1C=CC=NC1)C2=CC3=C(C=C2)C=CC=C3. References: Horley N J , Beresford K J M , Chawla T , et al. Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines[J]. European Journal of Medicinal Chemistry, 2017, 129:159-174.