2''-O-Galloylhyperin

2''-O-Galloylhyperin is a natural flavonoid that has been found in P. incarnata and has diverse biological activities, including antioxidant, anti-inflammatory, hepatoprotective, and transporter-inhibiting properties. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) and ABTS (Cay-27317) radicals (IC50s = 3 and 3.5 µM, respectively). It also inhibits human organic anion transporting polypeptide 1B1 (OATP1B1, IC50 = 19 µM in HEK293 cells). 2''-O-Galloylhyperin (15 µM) decreases LPS-induced IL-6 and TNF-alpha cytokine production from mouse RAW 264.7 macrophages. It also decreases LPS-induced mortality and liver damage in a mouse model of septic shock when administered at a dose of 50 mg/kg.Formal Name: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[[2-O-(3,4,5-trihydroxybenzoyl)-beta-D-galactopyranosyl]oxy]-4H-1-benzopyran-4-one. CAS Number: 53209-27-1. Synonyms: Hyperin-2''-Gallate. Molecular Formula: C28H24O16. Formula Weight: 616.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 260, 360 nm. SMILES: OC1=CC(O)=C2C(OC(C3=CC=C(O)C(O)=C3)=C(O[C@H]4[C@H](OC(C5=CC(O)=C(O)C(O)=C5)=O)[C@@H](O)[C@@H](O)[C@@H](CO)O4)C2=O)=C1. InChi Code: InChI=1S/C28H24O16/c29-8-18-21(37)23(39)26(43-27(40)10-4-15(34)20(36)16(35)5-10)28(42-18)44-25-22(38)19-14(33)6-11(30)7-17(19)41-24(25)9-1-2-12(31)13(32)3-9/h1-7,18,21,23,26,28-37,39H,8H2/t18-,21+,23+,26-,28+/m1/s1. InChi Key: PXGWEUQZDRUMRE-UNZYZCBSSA-N. Origin: Plant/Pyrola calliantha.