2-Iodomelatonin

Description: 2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, exhibiting over 5-fold selectivity for MT1 compared to MT2. It can be used to identify, characterize, and localize melatonin binding sites in the brain and peripheral tissues. Target: Melatonin Receptor. Smiles: COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1. References: Tomkinson A, et al. A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. J Immunol. 2001 May 1,166(9):5792-800.