2-Iodomelatonin

2-iodomelatonin is a potent agonist of melatonin receptor 1 (MT1, Ki = 28 pM) that is 5-fold selective for MT1 over MT2. It inhibits forskolin-stimulated cAMP production in CHO cells expressing human MT1 30-fold more potently than melatonin (Cay-14427) with an EC50 value of 11 pM. 2-iodomelatonin has been used to characterize the role of MT1 in melatonin-mediated signaling.Formal Name: N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]-acetamide. CAS Number: 93515-00-5. Molecular Formula: C13H15IN2O2. Formula Weight: 358.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 20 mg/ml. lambdamax: 214, 279 nm. SMILES: COC1=CC=C(NC(I)=C2CCNC(C)=O)C2=C1. InChi Code: InChI=1S/C13H15IN2O2/c1-8(17)15-6-5-10-11-7-9(18-2)3-4-12(11)16-13(10)14/h3-4,7,16H,5-6H2,1-2H3,(H,15,17). InChi Key: FJDDSMSDZHURBJ-UHFFFAOYSA-N.