2-Iminobiotin (hydrobromide)

2-Iminobiotin is a guanidine-modified derivative of the carboxylase coenzyme biotin (Cay-22582) and an inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS, Kis = 21.8 and 37.5 µM for the mouse and rat enzymes, respectively). It has been used to label and selectively retrieve sialoglycoproteins from erythrocyte ghosts. 2-Iminobiotin (0.2 mg/kg every four hours) prevents hypoxia-ischemia-induced decreases in brain phosphocreatine and ATP levels and increases in edema in the parietal cortex and striatum, as well as reduces apoptosis in the parietal- and temporal cortex and striatum, in piglets. It increases survival of, and decreases electrographic seizures in, hypoxia-ischemia-injured piglets when administered at doses of 0.2 and 1 mg/kg every four hours. Lipid nanoparticles (LNPs) containing 2-iminobiotin conjugated to poly-L-lysine have been used to improve LNP tumor targeting, uptake, and retention compared with LNPs containing biotin conjugated to poly-L-lysine in rats.Formal Name: [3aS-(3aalpha,4beta,6aalpha)]-2-amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-4-pentanoic acid, monohydrobromide. CAS Number: 76985-52-9. Synonyms: Guanidinobiotin. Molecular Formula: C10H17N3O2S . HBr. Formula Weight: 324.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: :, DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: sparingly soluble. SMILES: [H][C@](NC1=N)(CS[C@H]2CCCCC(O)=O)[C@@]2(N1)[H].Br. InChi Code: InChI=1S/C10H17N3O2S.BrH/c11-10-12-6-5-16-7(9(6)13-10)3-1-2-4-8(14)15,/h6-7,9H,1-5H2,(H,14,15)(H3,11,12,13),1H/t6-,7-,9-,/m0./s1. InChi Key: JKIJLCYOCQWMQL-UFLZEWODSA-N.