2-Hydroxyisocaproic Acid

2-Hydroxyisocaproic acid is a metabolite of L-leucine (Cay-34342) catabolism. It is formed from L-leucine via an alpha-ketoisocaproic acid (Cay-34749, Cay-21052) intermediate by hydroxyisocaproic acid dehydrogenase in L. lactis. 2-Hydroxyisocaproic acid is active against a variety of Gram-positive and -negative bacteria (IC50s = 0.6-4.5 mg/ml) and several Candida species (IC50s = 18-36 mg/ml). Dietary administration of 2-hydroxyisocaproic acid (50.4 g/kg) also prevents reductions in protein synthesis during the immobilization period and increases protein synthesis and muscle mass during the recovery period in casted animals in a rat model of immobilization-induced muscle atrophy.Formal Name: 2-hydroxy-4-methyl-pentanoic acid. CAS Number: 498-36-2. Synonyms: alpha-Hydroxyisocaproic Acid, 2-hydroxy-4-Methylvaleric Acid. Molecular Formula: C6H12O3. Formula Weight: 132.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 12 mg/ml, DMSO: 11 mg/ml, Ethanol: Slightly soluble, PBS (pH 7.2): 5 mg/ml. SMILES: O=C(C(CC(C)C)O)O. InChi Code: InChI=1S/C6H12O3/c1-4(2)3-5(7)6(8)9/h4-5,7H,3H2,1-2H3,(H,8,9). InChi Key: LVRFTAZAXQPQHI-UHFFFAOYSA-N.